The last man on earth is not alone. Somehow immune to an unstoppable, incurable virus, military virologist Robert Neville is now the last human survivng in New York City. He believes he may be the last human alive in the world. Mutant plague victims lurk in the shadows. They watch Robert's every move and wait for him to make a fatal mistake. Robert is driven by only one remaining mission - to find an antidote using his own immune blood. But, he is...

Welcome to the future where biological warfare has decimated life on Earth. Los Angeles is a windswept ghost town where Robert Neville tools his convertible through sunlit streets foraging for supplies. He fends off attacks by The Family-- sinister neopeople spawned by the plague. He also becomes a man with a mission after meeting Lisa, another infected survivor, and guardian of some healthy children representing our species' hope.