Dan Burns is a local newspaper advice columnist. He is a widower with three daughters. He brings the family to his parent's house for a family gathering. When Dan goes to a local bookstore, he meets Marie. When he gets home, he finds out that Marie is actually dating his brother Mitch. Dan's mother Nana announces that she met an old acquaintance of Dan's, Ruthie Draper and that she has set up a date between Dan and Ruthie. Dan refuses to go. Mitch...

The sleepy desert town of Prosperity, Arizona, is being menaced by giant arachnids that have mutated through exposure to toxic waste. The local sheriff and her teenage daughter work to prevent a complete takeover by the bloodthirsty spiders, getting valuable help from Prosperity's prodigal son, who's just returned to his embattled hometown.