During an electrical storm Jake Sherman turns into his tall, skinny, balding, and nerdy teacher Mr. Dirksen. Now, Jake and his sister Jessica have to work fast to get things back to normal.

Demonstrating an unusual machine to Andy, Jake Sherman accidentally turns his friend into the Sherman family dog, and when Andy's misbehavior lands him in obedience school, Jake must rescue him.

When Jake mysteriously switches bodies with an ugly alien he is forced to sit around watching television and eating junk food all day. At first he loves his new life, but by the time he realizes that he doesn't like being lazy, the aliens have stolen his body.

Barry Dunn is out of control. But since he beats kids up when they're off school property, nobody at "Burp it Up" Middle School can stop him. Jake Sherman has a plan- he makes his buddy Josh switch bodies with the principal. Principals can do anything. They can expel kids like Barry Dunn.

After they switched bodies with the lunch ladies, Jake and Andy swore they wouldn't use Mr. Dirksen's body-switching machine again, but Jake really wants to know what its like to be a professional wrestler. At Wrestle Insanity, Andy gets turned into Bruce "Brainiac" Bloom and Jake must switch bodies with Nick "No Nerve" Nelson in order to save him.